Title of article
Successful kinase bypass with new acyclovir phosphoramidate prodrugs
Author/Authors
Christopher McGuigan، نويسنده , , Marco Derudas، نويسنده , , Joachim J. Bugert، نويسنده , , Graciela Andrei، نويسنده , , Robert Snoeck، نويسنده , , Jan Balzarini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4364
To page
4367
Abstract
Novel phosphoramidates of acyclovir have been prepared and evaluated in vitro against acyclovir-sensitive and -resistant herpes simplex virus (HSV) types 1 and 2 and varicella-zoster virus (VZV). Unlike the parent nucleoside these novel phosphate prodrugs retain antiviral potency versus the ACV-resistant virus strain, suggesting an efficient bypass of the viral thymidine kinase.
Keywords
HSV , Protide , Thymidine kinase , nucleotides , prodrug
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799784
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