Title of article :
Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria
Author/Authors :
Bolin Geng، نويسنده , , Gloria Breault، نويسنده , , Janelle Comita-Prevoir، نويسنده , , Randy Petrichko، نويسنده , , Charles Eyermann، نويسنده , , Tomas Lundqvist، نويسنده , , Peter Doig، نويسنده , , Elise Gorseth، نويسنده , , Brian Noonan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
5
From page :
4368
To page :
4372
Abstract :
An early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained.
Keywords :
Glutamate racemase , MurI inhibitor , Benzyl purine
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2008
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
799785
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799785
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