Title of article
2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCθ
Author/Authors
L. Nathan Tumey، نويسنده , , Diane H. Boschelli، نويسنده , , Julie Lee، نويسنده , , Divya Chaudhary، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4420
To page
4423
Abstract
A series of 2-alkenyl thieno[2,3-b]pyridine inhibitors of PKCθ were synthesized as potential inflammatory modulators. This series led to the discovery of 2-alkenyl amides, which are exceptionally potent and selective inhibitors of PKCθ. Compound 8 has an IC50 of 3.8 nM against PKCθ and shows excellent selectivity over a variety of PKC isoforms.
Keywords
nitrile , kinase , PKC? , PKC , Cyano , T cell , inflammation , Indole , thienopyridine , PKC?
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799798
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