Title of article :
Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity
Author/Authors :
Richard Angell، نويسنده , , Nicola M. Aston، نويسنده , , Paul Bamborough، نويسنده , , Jacky B. Buckton، نويسنده , , Stuart Cockerill، نويسنده , , Suzanne J. deBoeck، نويسنده , , Chris D. Edwards، نويسنده , , Duncan S. Holmes، نويسنده , , Katherine L. Jones، نويسنده , , Dramane I. Lainé، نويسنده , , Shila Patel، نويسنده , , Penny A. Smee، نويسنده , , Kathryn J. Smith، نويسنده , , Don O. Somers، نويسنده , , Ann L. Walker، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
5
From page :
4428
To page :
4432
Abstract :
The biphenyl amides (BPAs) are a novel series of p38α MAP kinase inhibitor. The optimisation of the series to give compounds that are potent in an in vivo disease model is discussed. SAR is presented and rationalised with reference to the crystallographic binding mode.
Keywords :
CSBP , MAP kinase , inhibitors , Biphenyl amide , BPA , Biphenyl amides , Protein kinase X-ray structure , binding mode , structure-based drug design , Kinase selectivity , Structure–activity relationships , PG-PS model , p38 alpha , p38 kinase , CIA model , BPAs , p38
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2008
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
799800
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799800
بازگشت