Title of article :
Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: Effect of introduction of fluorine at the linker part
Author/Authors :
Jun-ichi Kasuga، نويسنده , , Takuji Oyama، نويسنده , , Yuko Hirakawa، نويسنده , , Makoto Makishima، نويسنده , , Kosuke Morikawa، نويسنده , , Yuichi Hashimoto، نويسنده , , Hiroyuki Miyachi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
We developed a potent peroxisome proliferator-activated receptor pan agonist (a candidate drug for treatment of altered metabolic homeostasis) by introducing fluorine atoms at appropriate position(s) of the known phenylpropionic acid-type pan agonist TIPP-703.
Keywords :
Fluorine , PPAR pan agonist , PPAR
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
