Title of article
Discovery of piperidine carboxamide TRPV1 antagonists
Author/Authors
Wing S. Cheung، نويسنده , , Raul R. Calvo، نويسنده , , Brett A. Tounge، نويسنده , , Sui-Po Zhang، نويسنده , , Dennis R. Stone، نويسنده , , Michael R. Brandt، نويسنده , , Tasha Hutchinson، نويسنده , , Christopher M. Flores، نويسنده , , Mark R. Player، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4569
To page
4572
Abstract
A series of piperidine carboxamides were developed as potent antagonists of the transient receptor potential vanilloid-1 (TRPV1), an emerging target for the treatment of pain. A focused library of polar head groups led to the identification of a benzoxazinone amide that afforded good potency in cell-based assays. Synthesis and a QSAR model will be presented.
Keywords
trpv1 , VR1 , Capsaicin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799831
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