Title of article
A synthetic method for peptide-PEG-lipid conjugates: Application of Octreotide-PEG-DSPE synthesis
Author/Authors
Jian-Chiou Su، نويسنده , , Chin-Lu Tseng، نويسنده , , Ting-Gung Chang، نويسنده , , Wen-Jen Yu، نويسنده , , Shih-Kwang Wu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4593
To page
4596
Abstract
A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG2000-DSPE (OPD2000) was used as an example to demonstrate the synthetic approach. The OPD2000 obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.
Keywords
Peptide-PEG-lipid conjugates , Octreotide , drug delivery , Targeted liposomes
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799837
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