A synthetic method for peptide-PEG-lipid conjugates: Application of Octreotide-PEG-DSPE synthesis

A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG2000-DSPE (OPD2000) was used as an example to demonstrate the synthetic approach. The OPD2000 obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.