Title of article
Parallel synthesis and antileishmanial activity of ether-linked phospholipids
Author/Authors
Paolo Coghi، نويسنده , , Nadia Vaiana، نويسنده , , Maria G. Pezzano، نويسنده , , Luca Rizzi، نويسنده , , Marcel Kaiser، نويسنده , , Reto Brun، نويسنده , , Sergio Romeo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
4658
To page
4660
Abstract
The synthesis and antileishmanial activity of 18 edelfosine analogues are described. Compounds were obtained in parallel combining solid phase and solution phase synthesis. The most active analogue is characterized by the octadecyl group in position 2 of the glycerol chain. Considering that this substitution determines the loss of antitumor activity, a different mechanism of antileishmanial action can be hypothesized.
Keywords
Antiprotozoal activity , parallel synthesis , Edelfosine , Leishmania donovani , Ether-linked phospholipids
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799853
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