Title of article
Effects of the aryl linker and the aromatic substituent on the anti-HCV activities of aryl diketoacid (ADK) analogues
Author/Authors
Jinyoung Kim، نويسنده , , Ki-Sun Kim، نويسنده , , Hyo Seon Lee، نويسنده , , Kwang Su Park، نويسنده , , Sun-Young Park، نويسنده , , Seock-Yong Kang، نويسنده , , Soo-Jae Lee، نويسنده , , Hyung Soon Park، نويسنده , , Dong-Eun Kim، نويسنده , , Youhoon Chong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
4661
To page
4665
Abstract
Based on our pharmacophore model of the aryl diketoacids (ADKs), we designed and prepared a series of novel ADK analogues, which showed potent inhibitory activities against the NS5B polymerase in the submicromolar range. Pharmacophore-guided docking study revealed that the antiviral activities of the ADKs are highly dependent upon the aryl linker as well as the size and position of the aromatic substituent. It is of another importance that, unlike previously reported ADKs, three ADK analogues synthesized in this study effectively blocked Hepatitis C Virus (HCV) replication in the replicon systems.
Keywords
Aryl linker , Hepatitis C virus (HCV) , Aryl diketoacid (ADK) , Pharmacophore-guided docking , Aromatic substituent
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799854
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