Author/Authors :
Jinyi Xu، نويسنده , , JingYi Yang، نويسنده , , Qian Ran، نويسنده , , Lei Wang، نويسنده , , Jie Liu، نويسنده , , Zhixuan Wang، نويسنده , , Xiaoming Wu، نويسنده , , Weiyi Hua، نويسنده , , Shengtao Yuan، نويسنده , , Luyong Zhang، نويسنده , , Mingqin Shen، نويسنده , , Yongfang Ding، نويسنده ,
Abstract :
Novel 1-O- and 14-O-derivatives of oridonin were synthesized and biologically evaluated. All of the derivatives exhibited stronger cytotoxicity against six cancer cell lines (BGC-7901, SW-480, HL-60, BEL-7402, A549, and B16) than oridonin in vitro, and some of them were more potent than oridonin and cyclophosphamide in vivo. Compounds Ib and IIg were the most potent with the IC50 values of 0.84 μM for Ib in HL-60 cell and 1.00 μM for IIg in BEL-7402 cell.
Keywords :
Oridonin , derivatives , cytotoxicity , Structure–activity relationships , anticancer
