Title of article
An osteoclast-targeting agent for imaging and therapy of bone metastasis
Author/Authors
Wei Liu، نويسنده , , Asghar Hajibeigi، نويسنده , , Mai-Lin Liang، نويسنده , , Cynthia L. Rostollan، نويسنده , , Zoltan Kovacs، نويسنده , , Orhan K. Oz، نويسنده , , Xiankai Sun، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
4789
To page
4793
Abstract
A hybrid compound (DO3A-BP) featuring a radiometal bifunctional chelator (1,4,7,10-tetraazacyclotetradecane-N,N′,N″,Ntriple prime-tetraacetic acid, DOTA) and an osteoclast-targeting moiety (bisphosphonate) was designed and synthesized. The 111In-labeled complex of DO3A-BP showed significantly elevated uptake in osteoclasts compared to the undifferentiated adherent bone marrow derived cells. Biodistribution studies revealed a favorable tissue distribution profile in normal mice with high bone uptake and long retention, and low or negligible accumulation in non-target organs.
Keywords
Bone metastasis , Imaging agent , Osteoclast , Bisphosphonate , Bifunctional chelator , Indium-111
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799888
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