Title of article
Structure–activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands
Author/Authors
Dragan Marinkovic، نويسنده , , Fabio C. Tucci، نويسنده , , Joe A. Tran، نويسنده , , Beth A. Fleck، نويسنده , , Jenny Wen، نويسنده , , Chen Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
4817
To page
4822
Abstract
A series of piperazinebenzylalcohols were prepared and studied to compare with their ketone and amine analogs as MC4R antagonists. Several benzylalcohols such as 14a and 14g displayed low nanomolar binding affinities (Ki < 10 nM), and high selectivities over other melanocortin receptor subtypes.
Keywords
synthesis , melanocortin , receptor , ligand , structure–activity relationship , Benzylalcohol , ketone , Amine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799897
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