Title of article :
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: Design, synthesis, and biological activity
Author/Authors :
Terry V. Hughes، نويسنده , , Guozhang Xu، نويسنده , , Steven K. Wetter، نويسنده , , Peter J. Connolly، نويسنده , , Stuart L. Emanuel، نويسنده , , Prabha Karnachi، نويسنده , , Scott R. Pollack، نويسنده , , Niranjan Pandey، نويسنده , , MARY ADAMS، نويسنده , , Sandra Moreno-Mazza، نويسنده , , Steven A. Middleton، نويسنده , , Lee M. Greenberger، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine was synthesized and found to have potent dual EGFR/HER2 kinase inhibitory activity. The structure-based drug design of this molecule as well as the kinase and cellular inhibition of HER2 kinase dependent cell lines will be discussed.
Keywords :
Intramolecular hydrogen bond , Restricted rotation , Oxadiazole , Quinazoline mimic , EGFR , kinase , HER1 , Pyrimidine , HER2
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
