Title of article
Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: A new class of selective norepinephrine reuptake inhibitors
Author/Authors
Casey C. McComas، نويسنده , , An T. Vu، نويسنده , , Paige E. Mahaney، نويسنده , , Stephen T. Cohn، نويسنده , , Andrew Fensome، نويسنده , , Michael A. Marella، نويسنده , , Lisa Nogle، نويسنده , , Eugene J. Trybulski، نويسنده , , Fei Ye، نويسنده , , Puwen Zhang، نويسنده , , Peter Alfinito، نويسنده , , Jenifer Bray، نويسنده , , Grace Johnston، نويسنده , , Elizabeth Koury، نويسنده , , Darlene C. Deecher، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
4929
To page
4931
Abstract
Norepinephrine and serotonin play an important role in a wide variety of biological processes and are implicated in a number of neurological disorders. A novel class of 1-(3-amino-1-phenylpropyl)indolin-2-ones was designed and synthesized that displays potent norepinephrine reuptake inhibition while maintaining high selectivity (>100-fold) against the human serotonin and dopamine transporters.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799918
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