Title of article
N-Alkyl-5H-pyrido[4,3-b]indol-1-amines and derivatives as novel urotensin-II receptor antagonists
Author/Authors
Yonghui Wang، نويسنده , , Zining Wu، نويسنده , , Brian F. Guida، نويسنده , , Sarah K. Lawrence، نويسنده , , Michael J. Neeb، نويسنده , , Ralph A. Rivero، نويسنده , , Stephen A. Douglas، نويسنده , , Jian Jin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4936
To page
4939
Abstract
High throughput screening of our compound collection led to the discovery of a novel series of N-alkyl-5H-pyrido[4,3-b]indol-1-amines as urotensin-II receptor antagonists. Synthesis, initial structure and activity relationships, functional and animal ortholog activities of the series are described.
Keywords
Urotensin-II receptor antagonist , UT antagonist , Pyridoindole amine , Competitive , Reversible , Functional antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799920
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