Title of article
New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter
Author/Authors
Nicola K. Jobson، نويسنده , , Andrew R. Crawford، نويسنده , , Deborah Dewar، نويسنده , , Sally L. Pimlott، نويسنده , , Andrew Sutherland، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4940
To page
4943
Abstract
A new route for the stereoselective synthesis of iodinated reboxetine analogues has been developed for the generation of SPECT imaging agents for the noradrenaline transporter (NAT). (2S,3S)- and (2R,3R)-iodoreboxetine were prepared and biological testing against various mono-amine transporters showed these compounds to be potent and selective for NAT.
Keywords
Stereoselective synthesis , SPECT , Transporter , noradrenaline , reboxetine , imaging
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799921
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