Title of article
Design and synthesis of fluorescent SGLT2 inhibitors
Author/Authors
Mark I. Lansdell، نويسنده , , Denise J. Burring، نويسنده , , David Hepworth، نويسنده , , Matthew Strawbridge، نويسنده , , Emily Graham، نويسنده , , Thierry Guyot، نويسنده , , Mark S. Betson، نويسنده , , James D. Hart، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4944
To page
4947
Abstract
The design and synthesis of the first fluorophore-conjugated SGLT2 inhibitors is described. The mode of linking the fluorophore to the SGLT2 pharmacophore was found to be crucial in achieving optimum potency. Superior potency to phlorizin was provided by examples containing TAMRA, BODIPY, Cy3B and NBD fluorophores.
Keywords
fluorophore , inhibitor , SGLT2 , conjugation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799922
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