Author/Authors :
Mark I. Lansdell، نويسنده , , Denise J. Burring، نويسنده , , David Hepworth، نويسنده , , Matthew Strawbridge، نويسنده , , Emily Graham، نويسنده , , Thierry Guyot، نويسنده , , Mark S. Betson، نويسنده , , James D. Hart، نويسنده ,
Abstract :
The design and synthesis of the first fluorophore-conjugated SGLT2 inhibitors is described. The mode of linking the fluorophore to the SGLT2 pharmacophore was found to be crucial in achieving optimum potency. Superior potency to phlorizin was provided by examples containing TAMRA, BODIPY, Cy3B and NBD fluorophores.
Keywords :
fluorophore , inhibitor , SGLT2 , conjugation
