Title of article :
Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A
Author/Authors :
Hong C. Shen، نويسنده , , Andrew K.P. Taggart، نويسنده , , Larissa C. Wilsie، نويسنده , , M. Gerard Waters، نويسنده , , Milton L. Hammond، نويسنده , , James R. Tata، نويسنده , , Steven L. Colletti، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Pyrazolopyrimidines were discovered as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A. In addition to its intrinsic activity, compound 9n significantly enhances nicotinic acid binding to the receptor, thereby potentiating the functional efficacy of nicotinic acid.
Keywords :
Allosteric agonists , Pyrazolopyrimidines , Nicotinic acid receptor , GPR109A
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
