• Title of article

    Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A

  • Author/Authors

    Hong C. Shen، نويسنده , , Andrew K.P. Taggart، نويسنده , , Larissa C. Wilsie، نويسنده , , M. Gerard Waters، نويسنده , , Milton L. Hammond، نويسنده , , James R. Tata، نويسنده , , Steven L. Colletti، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2008
  • Pages
    4
  • From page
    4948
  • To page
    4951
  • Abstract
    Pyrazolopyrimidines were discovered as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A. In addition to its intrinsic activity, compound 9n significantly enhances nicotinic acid binding to the receptor, thereby potentiating the functional efficacy of nicotinic acid.
  • Keywords
    Allosteric agonists , Pyrazolopyrimidines , Nicotinic acid receptor , GPR109A
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2008
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    799923

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799923