Title of article
Discovery of a novel class of PPARδ partial agonists
Author/Authors
Barry G. Shearer، نويسنده , , Hari S. Patel، نويسنده , , Andrew N. Billin، نويسنده , , James M. Way، نويسنده , , Deborah A. Winegar، نويسنده , , Millard H. Lambert and H. Eric Xu، نويسنده , , Robert X. Xu، نويسنده , , Lisa M. Leesnitzer، نويسنده , , Raymond V. Merrihew، نويسنده , , Stephane Huet، نويسنده , , Timothy M. Willson and Shawn P. Williams، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
5018
To page
5022
Abstract
Anthranilic acid GW9371 was identified as a novel class of PPARδ partial agonist through high-throughput screening. The design and synthesis of SAR analogues is described. GSK1115 and GSK7227 show potent partial agonism of the PPARδ target genes CPT1a and PDK4 in skeletal muscle cells.
Keywords
PDK4 , Partial agonist , CPT1a , PPARd
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799939
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