Title of article :
Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands
Author/Authors :
Robert Aslanian، نويسنده , , Xiaohong Zhu، نويسنده , , Henry A. Vaccaro، نويسنده , , Neng-Yang Shih، نويسنده , , John J. Piwinski، نويسنده , , Shirley M. Williams، نويسنده , , Robert E. West Jr.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A series of non-imidazole histamine H3 receptor antagonists based on the (3-phenoxypropyl)amine motif, which is a common pharmacophore for H3 antagonists, has been identified. A preliminary SAR study around the amine moiety has identified 8a as a potent H3 antagonist possessing a good pharmacokinetic profile in the rat.
Keywords :
hypoxia , Normoxia , PHD-2 , HIF-1a , Aza-benzimidazole , Prolyl hydroxylase
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
