Author/Authors :
Gerhard Pürstinger، نويسنده , , Armando M. De Palma، نويسنده , , Günther Zimmerhofer، نويسنده , , Simone Huber، نويسنده , , Sophie Ladurner، نويسنده , , Johan Neyts، نويسنده ,
Abstract :
The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and other enteroviruses at low-micromolar concentrations.
