Title of article :
Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors
Author/Authors :
Wilna J. Moree، نويسنده , , Phyllis Goldman، نويسنده , , Anthony J. Demaggio، نويسنده , , Erik Christenson، نويسنده , , Dan Herendeen، نويسنده , , John Eksterowicz، نويسنده , , Edward A. Kesicki، نويسنده , , David L. McElligott، نويسنده , , Graham Beaton، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
4
From page :
5126
To page :
5129
Abstract :
A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a cell based chemosensitization assay.
Keywords :
cancer , DNA repair , PARP-1 inhibitor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2008
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
799964
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799964
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