Title of article
Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors
Author/Authors
Wilna J. Moree، نويسنده , , Phyllis Goldman، نويسنده , , Anthony J. Demaggio، نويسنده , , Erik Christenson، نويسنده , , Dan Herendeen، نويسنده , , John Eksterowicz، نويسنده , , Edward A. Kesicki، نويسنده , , David L. McElligott، نويسنده , , Graham Beaton، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
5126
To page
5129
Abstract
A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a cell based chemosensitization assay.
Keywords
cancer , DNA repair , PARP-1 inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799964
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