Title of article :
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity
Author/Authors :
Terry V. Hughes، نويسنده , , Stuart L. Emanuel، نويسنده , , Harold R. O’Grady، نويسنده , , Peter J. Connolly، نويسنده , , Catherine Rugg، نويسنده , , Angel R. Fuentes-Pesquera، نويسنده , , Prabha Karnachi، نويسنده , , H. Richard Alexander، نويسنده , , Steven A. Middleton، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A novel series of 7-[1H-indol-2-yl]-2,3-dihydro-isoindol-1-ones designed to be inhibitors of VEGF-R2 kinase was synthesized and found to potently inhibit VEGF-R2 and Aurora-A kinases. The structure-based design, synthesis, and initial SAR of the series are discussed.
Keywords :
3-Dihydro-isoindol-1-ones , CANCER , Aurora-A , Aurora-B , Aurora-C , kinase , Vascular endothelial growth factor receptor 2 , VEGF-R2 , Isoindolinone , Kinase inhibition , 2
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
