Title of article
Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors
Author/Authors
Emmanuel Pinard، نويسنده , , Daniela Alberati، نويسنده , , Edilio Borroni، نويسنده , , Holger Fischer، نويسنده , , Dominik Hainzl، نويسنده , , Synèse Jolidon، نويسنده , , Jean-Luc Moreau، نويسنده , , Robert Narquizian، نويسنده , , Matthias Nettekoven، نويسنده , , Roger D. Norcross، نويسنده , , Henri Stalder، نويسنده , , Andrew W. Thomas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
5134
To page
5139
Abstract
Screening of the Roche compound library led to the identification of the benzoylpiperazine 7 as a structurally novel GlyT1 inhibitor. The SAR which was developed in this series resulted in the discovery of highly potent compounds displaying excellent selectivity against the GlyT2 isoform, drug-like properties, and in vivo efficacy after oral administration.
Keywords
Benzoylpiperazine , Transporter , Glycine , Schizophrenia , NMDA , GlyT1 , inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799966
Link To Document