Title of article
Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors
Author/Authors
Emily J. Hanan، نويسنده , , Raymond V. Fucini، نويسنده , , Michael J. Romanowski، نويسنده , , Robert A. Elling and David K. Wilson، نويسنده , , Willard Lew، نويسنده , , Hans E. Purkey، نويسنده , , Erica C. VanderPorten، نويسنده , , Wenjin Yang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
5186
To page
5189
Abstract
A series of 2-amino-isoxazolopyridines was designed and synthesized as Polo-like kinase (Plk) inhibitors. Key SAR and crystallographic data are discussed. More advanced analogues inhibit Plk1 with good enzymatic activity and modest cell-based activity. Differential selectivity among the three Plk isoforms is observed.
Keywords
kinase inhibitor , 2-Amino-isoxazolopyridines , Polo-like kinase (Plk) , SAR
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799976
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