Title of article
New functionalized 1,2,4-trioxepanes: Synthesis and antimalarial activity against multi-drug resistant P. yoelii in mice
Author/Authors
Chandan Singh، نويسنده , , Shilpi Pandey، نويسنده , , Ambuj K. Kushwaha، نويسنده , , Sunil K. Puri، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
5190
To page
5193
Abstract
A series of new amino functionalized 1,2,4-trioxepanes 8–16 and ester functionalized 1,2,4-trioxepanes 17–19 have been synthesized and evaluated against multi-drug resistant Plasmodium yoelii in Swiss mice. Amino functionalized trioxepanes 14, the most active compound of the series, showed 100% clearance of parasitaemia by oral route on day 4 and 75% protection to the treated mice beyond day 28.
Keywords
2 , 4-trioxane , 1 , 2 , Ester functionalized trioxepane , Amino functionalized trioxepane , antimalarial , 1 , Artemisinin , 4-Trioxepane
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799977
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