Title of article :
Novel BK channel openers containing dehydroabietic acid skeleton: Structure–activity relationship for peripheral substituents on ring C
Author/Authors :
Yong-Mei Cui، نويسنده , , Eriko Yasutomi، نويسنده , , Yuko Otani، نويسنده , , Takashi Yoshinaga، نويسنده , , Katsutoshi Ido، نويسنده , , Kohei Sawada، نويسنده , , Tomohiko Ohwada، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A series of dehydroabietic acid (DHAA, 2) derivatives was synthesized and evaluated as BK channel openers in an assay system of CHO-K1 cells expressing hBKα channels. Systematic modifications of the peripheral functionality of ring C of DHAA showed that the introduction of a nitro or (thio)urea group in ring C greatly enhanced the BK channel-opening activity.
Keywords :
Dehydroabietic acid , BK channels , SAR studies , Openers , Thiourea
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
