Title of article
Novel BK channel openers containing dehydroabietic acid skeleton: Structure–activity relationship for peripheral substituents on ring C
Author/Authors
Yong-Mei Cui، نويسنده , , Eriko Yasutomi، نويسنده , , Yuko Otani، نويسنده , , Takashi Yoshinaga، نويسنده , , Katsutoshi Ido، نويسنده , , Kohei Sawada، نويسنده , , Tomohiko Ohwada، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
5201
To page
5205
Abstract
A series of dehydroabietic acid (DHAA, 2) derivatives was synthesized and evaluated as BK channel openers in an assay system of CHO-K1 cells expressing hBKα channels. Systematic modifications of the peripheral functionality of ring C of DHAA showed that the introduction of a nitro or (thio)urea group in ring C greatly enhanced the BK channel-opening activity.
Keywords
Dehydroabietic acid , BK channels , SAR studies , Openers , Thiourea
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799980
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