Title of article
Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors
Author/Authors
Kevin M. Guckian، نويسنده , , Edward Yin-Shiang Lin، نويسنده , , Laura Silvian، نويسنده , , Jessica E. Friedman، نويسنده , , Donovan Chin، نويسنده , , Daniel M. Scott، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
5249
To page
5251
Abstract
A series of meta-substituted anilines were designed and synthesized to inhibit the interaction of LFA-1 with ICAM for the treatment of autoimmune disease. Design of these molecules was performed by utilizing a co-crystal structure for structure-based drug design. The resulting molecules were found to be potent and to possess favorable pharmaceutical properties.
Keywords
LFA-1 , ICAM , I-domain , LFA-1/ICAM inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799991
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