Title of article
Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis
Author/Authors
Meng Li، نويسنده , , Zhi Chen، نويسنده , , Xiuping Lin، نويسنده , , Xuan Zhang، نويسنده , , Yuan Song، نويسنده , , Ying Wen، نويسنده , , Jilun Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
5359
To page
5363
Abstract
Two new recombinants of avermectin polyketide synthases were constructed by domain and module swapping in Streptomyces avermitilis 73-12. However, only the strain, S. avermitilis OI-31, formed by domain substitution could produce ivermectin. Analysis of the ivermectin synthesized gene cluster showed that decreased amount of aveC transcripts was one of the factors causing low yield of ivermectin. Overexpression of aveC could improve ivermectin yield.
Keywords
Combinatorial biosynthesis , ivermectin , Avermectin , aveC , Polyketide synthase , Streptomyces avermitilis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800012
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