Title of article
A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity
Author/Authors
Victoria Magrioti، نويسنده , , George Naxakis، نويسنده , , Dimitra Hadjipavlou-Litina، نويسنده , , Alexandros Makriyannis، نويسنده , , George Kokotos، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
5424
To page
5427
Abstract
A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (Ki 21.8 μM) without significantly affecting FAAH. This compound exhibited interesting in vivo analgesic and anti-inflammatory properties, suggesting that selective inhibitors of MGL may be valuable novel agents for the treatment of inflammatory pain.
Keywords
Endocannabinoids , 2-Diamines , Fatty acid amide hydrolase , Monoacyglycerol lipase , MGL , inhibitor , FAAH , 1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800027
Link To Document