Title of article
2,4(5)-Diarylimidazoles: Synthesis and biological evaluation of a new class of sodium channel blockers against hNav1.2
Author/Authors
Mirko Rivara، نويسنده , , Aparna R. Baheti، نويسنده , , Marco Fantini، نويسنده , , Giuseppe Cocconcelli، نويسنده , , Chiara Ghiron، نويسنده , , Christopher L. Kalmar، نويسنده , , Natasha Singh، نويسنده , , Ellen C. Merrick، نويسنده , , Manoj K. Patel، نويسنده , , Valentina Zuliani، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
5460
To page
5462
Abstract
A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential inhibitors of hNav1.2 sodium channel currents. One member of this series (4) exhibited profound inhibition of Nav1.2 currents, emerging as a promising lead compound for further structure–activity relationship studies for the development of novel sodium channel blockers.
Keywords
sodium channel , parallel synthesis , Diarylimidazoles
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800036
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