Author/Authors :
Mirko Rivara، نويسنده , , Aparna R. Baheti، نويسنده , , Marco Fantini، نويسنده , , Giuseppe Cocconcelli، نويسنده , , Chiara Ghiron، نويسنده , , Christopher L. Kalmar، نويسنده , , Natasha Singh، نويسنده , , Ellen C. Merrick، نويسنده , , Manoj K. Patel، نويسنده , , Valentina Zuliani، نويسنده ,
Abstract :
A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential inhibitors of hNav1.2 sodium channel currents. One member of this series (4) exhibited profound inhibition of Nav1.2 currents, emerging as a promising lead compound for further structure–activity relationship studies for the development of novel sodium channel blockers.
