Title of article
Synthesis and antibacterial activity of 4″-O-heteroarylcarbamoyl derivatives of macrolide
Author/Authors
Peng Xu، نويسنده , , Lu Liu، نويسنده , , Zhiping Jin، نويسنده , , Guang-qiang Wang، نويسنده , , Jian Liu، نويسنده , , Yun Li، نويسنده , , Ping-sheng Lei، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
5507
To page
5511
Abstract
A series of novel 4″-position modified macrolide derivatives has been synthesized via a facile procedure. Their in vitro antibacterial activities against constitutively erythromycin-resistant strains were evaluated. Among the derivatives tested, compound 8a which has 11,12-carbamate and 4″-O-heteroarylcarbamoyl groups was found to have potent activity against most resistant bacteria.
Keywords
4?-Modified macrolide , synthesis , macrolide resistance
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800046
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