Title of article :
Eicosapentaenoic-acid-derived isoprostanes: Synthesis and discovery of two major isoprostanes
Author/Authors :
Chih-Tsung Chang، نويسنده , , Pranav Patel، نويسنده , , Namin Kang، نويسنده , , John A. Lawson، نويسنده , , Wen-Liang Song، نويسنده , , William S. Powell، نويسنده , , Garret A. FitzGerald، نويسنده , , Joshua Rokach، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The stereospecific synthesis of two all-syn-EPA-derived isoprostanes (iPs), 5-epi-8,12-iso-iPF3α-VI 17 and 8,12-iso-iPF3α-VI 18, has been accomplished. These two synthetic probes have been used to discover and identify their presence in human urine. The eventual quantitative measurement of these two iPs may be a valuable index of oxidative stress in people with eicosapentaenoic acid- (EPA) and docosahexaenoic acid- (DHA) enriched phospholipids.
Keywords :
arachidonic acid , DHA , IP , docosahexaenoic acid , Epa , AA , Isoprostane , Eicosapentaenoic acid
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
