Title of article
Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent
Author/Authors
Harikishore Pingali، نويسنده , , Mukul Jain، نويسنده , , Shailesh Shah، نويسنده , , Sujay Basu، نويسنده , , Pankaj Makadia، نويسنده , , Amitgiri Goswami، نويسنده , , Pandurang Zaware، نويسنده , , Pravin Patil، نويسنده , , Atul Godha، نويسنده , , Suresh Giri، نويسنده , , Ashish Goel، نويسنده , , Megha Patel، نويسنده , , Harilal Patel، نويسنده , , Pankaj Patel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
5586
To page
5590
Abstract
A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and substituted phenyl group as a lipophilic tail have been prepared as agonists of PPARα and γ. c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid 13c exhibited potent hypoglycemic and lipid lowering activity with high oral bioavailability in animal models.
Keywords
3-Dioxane-2 carboxylic acid , Metabolic disorders , Type 2 diabetes , 1 , PPAR agonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800063
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