Title of article
Small, non-peptide C5a receptor antagonists: Part 1
Author/Authors
Julian Blagg، نويسنده , , Charles Mowbray، نويسنده , , David C. Pryde، نويسنده , , Gary Salmon، نويسنده , , Esther Schmid، نويسنده , , David Fairman، نويسنده , , Kevin Beaumont، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
5601
To page
5604
Abstract
The optimisation of a series of amides for C5a receptor binding and functional activity, and physicochemical properties is described. The initial hit, 1 (IC50 1 μM), was discovered during high throughput screening, from which highly potent C5a receptor antagonists (e.g. 14, IC50 5 nM) were developed.
Keywords
Antagonist , complement , inflammation , C5a receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800067
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