Title of article :
Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP
Author/Authors :
Hongbin Yan، نويسنده , , Xiaolu Wang، نويسنده , , Rhonda KuoLee، نويسنده , , Wangxue Chen، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The synthesis of mono- and bisphosphorothioate analogues of 3′,5′-cyclic diguanylic acid (cdiGMP) via the modified H-phosphonate chemistry is reported. The immunostimulatory properties of these analogues were compared with those of cdiGMP.
Keywords :
Vaccine adjuvant , cdiGMP , Immunostimulation , phosphorothioate
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
