Author/Authors :
Steven M. Bromidge، نويسنده , , Barbara Bertani، نويسنده , , Manuela Borriello، نويسنده , , Stefania Faedo، نويسنده , , Laurie J. Gordon، نويسنده , , Enrica Granci، نويسنده , , Matthew Hill، نويسنده , , Howard R. Marshall، نويسنده , , Luigi P. Stasi، نويسنده , , Valeria Zucchelli، نويسنده , , Giancarlo Merlo، نويسنده , , Alessia Vesentini، نويسنده , , Jeannette M. Watson، نويسنده , , Laura Zonzini، نويسنده ,
Abstract :
Investigation of a series 6-[2-(4-aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones has led to the discovery of potent 5-HT1A/1B/1D receptor antagonists with and without additional SerT affinity. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization.
Keywords :
5-HT1A/1B/1D receptor antagonists , Serotonin reuptake inhibitors , Antidepressant , 5-HT1 autoreceptors
