Title of article :
Novel design principle validated: Glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent
Author/Authors :
L?szl? Soms?k، نويسنده , , Veronika Nagy، نويسنده , , Sébastien Vidal، نويسنده , , Katalin Czifr?k، نويسنده , , Eszter Berzsényi، نويسنده , , Jean-Pierre Praly، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
2-Naphthyl-substituted glucopyranosylidene-spiro-oxathiazole prepared following a novel design principle was found to be the best known glucose analogue inhibitor of rabbit muscle glycogen phosphorylase b (Ki 160 nM).
Keywords :
Oxathiazole , Spirocyclization , Spiro-bicyclic sugar , Glycogen phosphorylase , inhibitor , Glucose analogue
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
