Title of article
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors
Author/Authors
Kirk L. Stevens، نويسنده , , Michael J. Reno، نويسنده , , Jennifer B. Alberti، نويسنده , , Daniel J. Price، نويسنده , , Laurie S. Kane-Carson، نويسنده , , Victoria B. Knick، نويسنده , , Lisa M. Shewchuk، نويسنده , , Anne M. Hassell، نويسنده , , James M. Veal، نويسنده , , Stephen T. Davis، نويسنده , , Robert J. Griffin، نويسنده , , Michael R. Peel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
5758
To page
5762
Abstract
A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependant kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions on the pyrazolopyridazine core provided potent inhibitors of CDK4 and demonstrated enzyme selectivity against VEGFR-2 and GSK3β.
Keywords
cancer , Cyclin-dependant kinase inhibitor , CDK2 , Cdk4 , VEGFR-2 , GSK3? , 5-b] pyridazine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800103
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