Title of article
Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl
Author/Authors
Christian O. Janssen، نويسنده , , Stephanie Lim، نويسنده , , Ee Peng Lo، نويسنده , , Kah Fei Wan، نويسنده , , Victor C. Yu، نويسنده , , May-Ann Lee، نويسنده , , Siew Bee Ng، نويسنده , , Martin J. Everett، نويسنده , , Antony D. Buss، نويسنده , , David P. Lane، نويسنده , , Rustum S. Boyce، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
5771
To page
5773
Abstract
The cytotoxic macrolide kendomycin was identified as a ligand of Bcl-xl, an anti-apoptotic member of the Bcl-2 protein family. Hydrolysis-stable and protonable semi-synthetic analogues have been obtained that retain cytotoxicity and Bcl-xl binding.
Keywords
Bcl-2 , Kendomycin , Apoptotic , Semi-synthetic , bcl-XL , Ketal , High-throughput screening
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800106
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