Title of article :
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies
Author/Authors :
Marco Radi، نويسنده , , Lucilla Angeli، نويسنده , , Luigi Franchi، نويسنده , , Lorenzo Contemori، نويسنده , , Giovanni Maga، نويسنده , , Alberta Samuele، نويسنده , , Samantha Zanoli، نويسنده , , Mercedes Armand-Ugon، نويسنده , , Emmanuel Gonzalez MD، نويسنده , , Anuska Llano، نويسنده , , José A. Esté، نويسنده , , Maurizio Botta، نويسنده ,
Abstract :
A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.
Keywords :
HIV-1 , reverse transcriptase , mutant , NNRTIs , S-DABOCs , Molecular modeling
