Title of article
Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta
Author/Authors
Yongsheng Liu، نويسنده , , Jiangyue Wu، نويسنده , , Helge Weissig، نويسنده , , Juan M. Betancort، نويسنده , , Wen Zhi Gai، نويسنده , , Phillip S. Leventhal، نويسنده , , Matthew P. Patricelli، نويسنده , , Babak Samii، نويسنده , , Anna K. Szardenings، نويسنده , , Kevin R. Shreder، نويسنده , , John W. Kozarich and Adrian Goldman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
5955
To page
5958
Abstract
The synthesis and biochemical characterization of AX4697, a fluorescent, bisindolylmaleimide-derived probe for PKCα and β, is described. AX4697 was able to quantify changes in PKC expression in drug-treated Jurkat cells and was shown to covalently label PKCα on C619, a residue that sits just outside the active site.
Keywords
Kinase probe , PKC? , Exo-affinity label , Bisindolylmaleimide , PKC?
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800148
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