Synthesis and structural study of cyclic 5-aminovaleric acid-linked β-Ala–β-Ala dipeptides

5-Aminovaleric acid and ornithine were evaluated as linkers for the cyclization of β-dipeptides. Two linked examples of β-Ala-β-Ala were prepared by standard coupling methods and their conformations probed by NMR, CD, and computational means. The data suggest that these non- or monosubstituted versions of the target compounds are flexible in solution.