Title of article :
Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246
Author/Authors :
Yoshihito Shiono، نويسنده , , Keiko Shimanuki، نويسنده , , Fuminori Hiramatsu، نويسنده , , Takuya Koseki، نويسنده , , Murayama Tetsuya، نويسنده , , Nozomi Fujisawa، نويسنده , , Kenichi Kimura، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher’s method. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells.
Keywords :
Pyrrospirones , endophyte , Pyrrocidines , Neonectria ramulariae
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
