Author/Authors :
Puwen Zhang، نويسنده , , Eugene A. Terefenko، نويسنده , , Casey C. McComas، نويسنده , , Paige E. Mahaney، نويسنده , , An Vu، نويسنده , , Eugene Trybulski، نويسنده , , Elizabeth Koury، نويسنده , , Grace Johnston، نويسنده , , Jenifer Bray، نويسنده , , Darlene Deecher، نويسنده ,
Abstract :
A series of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors was discovered. Several compounds such as 15 and 20 showed good hNET potency. Compounds 15 and 20 also displayed excellent selectivity at hNET that appeared superior to those of reboxetine and atomoxetine (4 and 5).
Keywords :
Serotonin reuptake inhibitor , Norepinephrine reuptake inhibitor , Dopamine reuptake inhibitor , 3-dihydro-2H-benzimidazol-2-ones , 3-(3-Amino-1-phenyl propyl)-1 , NRI
