Title of article
Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors
Author/Authors
Puwen Zhang، نويسنده , , Eugene A. Terefenko، نويسنده , , Casey C. McComas، نويسنده , , Paige E. Mahaney، نويسنده , , An Vu، نويسنده , , Eugene Trybulski، نويسنده , , Elizabeth Koury، نويسنده , , Grace Johnston، نويسنده , , Jenifer Bray، نويسنده , , Darlene Deecher، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
6067
To page
6070
Abstract
A series of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors was discovered. Several compounds such as 15 and 20 showed good hNET potency. Compounds 15 and 20 also displayed excellent selectivity at hNET that appeared superior to those of reboxetine and atomoxetine (4 and 5).
Keywords
Serotonin reuptake inhibitor , Norepinephrine reuptake inhibitor , Dopamine reuptake inhibitor , 3-dihydro-2H-benzimidazol-2-ones , 3-(3-Amino-1-phenyl propyl)-1 , NRI
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800171
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