Title of article
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)
Author/Authors
Luc J. Farmer، نويسنده , , Guy Bemis، نويسنده , , Shawn D. Britt، نويسنده , , John Cochran، نويسنده , , Martin Connors، نويسنده , , Edmund M. Harrington، نويسنده , , Thomas Hoock، نويسنده , , William Markland، نويسنده , , Suganthini Nanthakumar، نويسنده , , Paul Taslimi، نويسنده , , Ernst ter Haar، نويسنده , , Jian Wang، نويسنده , , Darshana Zhaveri، نويسنده , , Francesco G. Salituro، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
6231
To page
6235
Abstract
A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar Ki’s against SYK and potent inhibition in mast cell degranulation assays.
Keywords
Spleen tyrosine kinase , SYK , asthma
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800209
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