مرکز منطقه ای اطلاع رساني علوم و فناوري - Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

Title of article :

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

Author/Authors :

Luc J. Farmer، نويسنده , , Guy Bemis، نويسنده , , Shawn D. Britt، نويسنده , , John Cochran، نويسنده , , Martin Connors، نويسنده , , Edmund M. Harrington، نويسنده , , Thomas Hoock، نويسنده , , William Markland، نويسنده , , Suganthini Nanthakumar، نويسنده , , Paul Taslimi، نويسنده , , Ernst ter Haar، نويسنده , , Jian Wang، نويسنده , , Darshana Zhaveri، نويسنده , , Francesco G. Salituro، نويسنده ,

Issue Information :

روزنامه با شماره پیاپی سال 2008

Pages :

From page :

6231

To page :

6235

Abstract :

A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar Ki’s against SYK and potent inhibition in mast cell degranulation assays.

Keywords :

Spleen tyrosine kinase , SYK , asthma

Journal title :

Bioorganic & Medicinal Chemistry Letters

Serial Year :

2008

Journal title :

Bioorganic & Medicinal Chemistry Letters

Record number :

800209

Link To Document :

https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=800209