Title of article
Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis
Author/Authors
Brendan L. Wilkinson، نويسنده , , Hilary Long، نويسنده , , Edith Sim، نويسنده , , Antony J. Fairbanks، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
6265
To page
6267
Abstract
A series of arabino glycosyl triazoles with varying hydrophobic groups were synthesised as putative mimics of decaprenolphosphoarabinose (DPA) as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity, with strong dependence on the identity of the hydrophobic side chain.
Keywords
carbohydrates , Glycosyl triazoles , click chemistry , Arabinose , mycobacteria , tuberculosis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800217
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