Author/Authors :
Tünde Moln?r، نويسنده , , J?lia Visy، نويسنده , , ?gnes Simon، نويسنده , , Istv?n Moldvai، نويسنده , , Eszter Temesv?ri-Major، نويسنده , , G?bor D?rnyei، نويسنده , , Erzsébet K?tiné Fekete، نويسنده , , Julianna Kardos، نويسنده ,
Abstract :
Gamma-hydroxybutyric acid (GHB) binding to multiple sites for the tricarboxylic acid cycle intermediate succinic acid (SUC) has been disclosed recently. In order to better characterize these targets, distinguishable binding of GHB receptor-specific NCS 382 antipodes to [3H]-SUC or [3H]-GHB labelled sites in rat brain synaptic membranes was explored. Eutomer binding parameters suggest identity of the high-affinity target for SUC with a synaptic GHB receptor subtype.
