Title of article
New cyclic tetrapeptides from Nonomuraea sp. TA-0426 that inhibit glycine transporter type 1 (GlyT1)
Author/Authors
Yuichi Terui، نويسنده , , Yi-wen Chu، نويسنده , , Jun-ying Li، نويسنده , , Tsutomu Ando، نويسنده , , Takuya Fukunaga، نويسنده , , Takeshi Aoki، نويسنده , , Yoshihisa Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
6321
To page
6323
Abstract
In the course of our search for natural antipsychotic agents, we isolated five new cyclic tetrapeptides from the fermentation broth of Nonomuraea sp. TA-0426. These compounds turned out to be analogues of WSS2220, which had been produced by the same actinomycete and showed strong inhibitory activity against GlyT1. Four of the present peptides exhibit more potent GlyT1 inhibitory activities than WSS2220.
Keywords
WSS2220 , GlyT1 inhibitor , WSS2219 , Cyclic tetrapeptide , GlyT1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800226
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