Title of article
Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology
Author/Authors
Toru Nemoto، نويسنده , , Hideaki Fujii، نويسنده , , Minoru Narita، نويسنده , , Kan Miyoshi، نويسنده , , Atsushi Nakamura، نويسنده , , Tsutomu Suzuki and Osamu Nureki، نويسنده , , Hiroshi Nagase، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
6398
To page
6401
Abstract
A novel 6,14-epoxymorphinan benzamide derivative (NS22) was synthesized, which showed opioid κ receptor agonistic activity in the [35S]GTPγS binding assay. The antinociceptive effect of NS22 was evaluated in the tail-flick and the hot-plate test. This compound showed a potent antinociceptive activity in mice by sc administration, which was attenuated with nor-BNI (selective opioid κ receptor antagonist).
Keywords
analgesics , 6 , Naltrexone , Opioid , 14-Epoxymorphinan
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800244
Link To Document